Category: 125995-03-1

Electric Literature of 125995-03-1, An article , which mentions 125995-03-1, molecular formula is C33H33FN2O4. The compound – Atorvastatin lactone played an important role in people’s production and life.

3,5,N-TRIHYDROXY-ALKANAMIDE AND DERIVATIVES: METHOD FOR MAKING SAME AND USE THEREOF

The present invention provides novel compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds and pharmaceutical compositions for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, and a disease associated with oxidative stress), or inhibiting drug resistance of cancer cells

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

125995-03-1, Name is Atorvastatin lactone, molecular formula is C33H33FN2O4, belongs to Tetrahydropyrans compound, is a common compound. In a patnet, once mentioned the new application about 125995-03-1, Computed Properties of C33H33FN2O4

In situ assessment of atorvastatin impurity using MALDI mass spectrometry imaging (MALDI-MSI)

The analysis of impurities and degradation products in pharmaceutical preparations are usually performed by chromatographic techniques such as high-performance liquid chromatography (HPLC). This approach demands extensive analysis time, mostly due to extraction and separation phases. These steps must be carried out in samples in order to adapt them to the requirements of the analytical method of choice. In the present contribution, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was employed to quantify an important degradation product in atorvastatin calcium 80. mg tablets: the atorvastatin lactone. Through the standard of the impurity, it was possible to perform quantitative analysis directly on the drug tablet, using a quick and novel approach, suitable for quality control processes in the pharmaceutical industry.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C33H33FN2O4. In my other articles, you can also check out more blogs about 125995-03-1

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 42 (51 mg, 94 muiotaetaomicron) in THF (0521) (0.5 mL) was added hydroxylamine (50% in water, 16 (0522) mu, 0.47 mmol). The resulting mixture was stirred for (0523) 48 h. Next, the mixture was concentrated under (0524) reduced pressure, stripped with CH2C12 (2 x 10 mL) (0525) and dried in vacuo to yield 44 (53 mg, 99%) as a white (0526) foam. NMR (400 MHz, CDCI3) delta 7.22-6.79 (m, 14H), 4.22-3.82 (m, 3H), 3.70-3.40 (0527) (m, 2H), 2.28-2.02 (m, 2H), 1.70-1.08 (m, 10H)., 125995-03-1

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Reference£º
Patent; STICHTING KATHOLIEKE UNIVERSITEIT; SCHIRRIS, Tom Johan Joseph; RITSCHEL, Tina; RUTJES, Floris Petrus Johannes Theodorus; SMEITINK, Johannes Albertus Maria; RUSSEL, Francois Gerard Marie; (92 pag.)WO2017/137469; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.

Example 14 ; (2R,4R)-1-{2-[4-(tert-Butyldimethylsilyloxy)-6-oxotetrahydro-2-pyranyl]-ethyl}-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide; (23) (synthesis from Atorvastatin) was prepared in 92% yield according to WO 2005/012246 A1. [Show Image] LC-MS (ESI+) m/z 655 (M+1)., 125995-03-1

As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.

Reference£º
Patent; Ratiopharm GmbH; EP1834944; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the residue 95 kg of methanol and NaOH solution ( 2 eqv. 3.28 kg NaOH was dissolved in 26.7 kg of water) were added. The mixture was stirred at 35-45 0C for 30-40 minutes. TLC analysis showed that all the starting materials were converted into the sodium salt of Atorvastatin., 125995-03-1

125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ULKAR KIMYA SAN. VE TIC. A.S.; WO2009/82362; (2009); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.

A magnetic stirrer of appropriate size was added to a 50 ml reaction tube, the air was replaced and protected with nitrogen, 30 ml of methylene chloride was injected, and the reaction vessel was placed in a low-temperature stirring reaction bath (Below -65 C), inject 0.75 ml of diethylaminosulfur trifluoride by injection at low temperature, stir for about 15 minutes, then slowly add 1.50 g of atorvastatin lactone in 5 ml of dichloromethane. After stirring the reaction for about 30 minutes, about 0.3 ml of triethylamine was added by syringe, and after 2 hours, the reaction was naturally warmed up overnight. After the reaction was monitored by TLC, the filtrate was filtered and the filtrate was dried over anhydrous sodium sulfate. The residue was spin-dried and separated by column chromatography (PE / EA gradient elution) to obtain 0.76 g of atorvastatin fluoride product (001).

125995-03-1, As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.

Reference£º
Patent; Shanghai Applied Technology College; Shanghai Huali Bio-pharmaceutical Co., Ltd.; Wang Zhonghua; Wu Fanhong; Li Bing; Yu Xiaodong; Lv Qianqian; Wu Chuang; Su Feifei; Wu Fulong; (23 pag.)CN105085497; (2017); B;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The lactone (V) ( 100.0 g, 0.185 mol) was dissolved in THF (500 ml) and reacted with the suspension of calcium hydroxide ( 18.68 g, 0.185 mol) in water ( 100 ml) and stirred at 45 to 5O0C. After the reaction was(2 hrs), the mixture was poured into water (1.0 It), extracted twice with dichloromethane (3.0 It and 1.0 It each), the combined organic layer was optionally washed with water( 250 ml and concentrated to approx 700 ml at 40 to 420C. The concentrated layer was fine filtered through Whatman paper, cooled to 10 to 150C and diisopropyl ether (3.0 It) was then added to the mixture keeping the temperature below 150C. After stirring for 15 min, the precipitated solid was filtered, washed with cold diisopropyl ether and dried at 55 to 600C under vacuum for 24 hrs. Yield: 101.8 g (95.1 %); Purity (HPLC): 99.55 %, Assay (HPLC): 99.21 %: Calcium content: 3.33%; Moisture content (by K. F): 1.81 %;Residual solvents: Methanol < 0.05 %, THF < 0.05 %, Dichloromethane < 0.02 %, Diisopropyl ether < 0.01 %. 125995-03-1, As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.

Reference£º
Patent; MOREPEN LABORATORIES LIMITED; WO2006/48893; (2006); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 3: Preparation of crystalline Form III of atorvastatin strontium salt50.0 g of atorvastatin lactone was suspended in a mixture of 200 ml of t-butyl methyl ether and 200 ml of methanol, and 3.7 g of strontium hydroxide dissolved in 200m? of water was slowly added thereto over 30 minutes, and stirred at room temperature for 3 hours. After removing the organic layer, 150 ml of t-butyl methyl ether was added to the aqueous layer, followed by stirring at room temperature for 10 minutes. The organic layer was again removed, and 50 ml of methanol, 150 ml of t-butyl methyl ether and 650 ml of distilled water were successively added to the aqueous layer. The mixture was warmed to 50 C, to which 10.2 g of strontium acetate dissolved in 250 ml of water was slowly added over 2 hours, stirred at 50 C for 17 hours, and the resulting solution was cooled to room temperature. The precipitate formed was filtered, washed with a mixture of 100 ml of methanol and 50 ml of water and dried in air, to obtain 43 g of the title compound (yield: 77%) as a white crystalline powder.Moisture content (Karl-Fisher titrator): about 5.5%The XRPD result of the crystalline powder obtained above showed that the crystalline powder is a crystal having distinctively characteristic main peaks (those having 1/I0 of at least 10%), as shown in Table 3. Accordingly, the crystalline powder is designated Form III.

125995-03-1, As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.

Reference£º
Patent; HANMI PHARM. CO., LTD.; WO2008/93951; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The lactone (1.1g) was dissolved in ethanol (10ML). Water (2ml) and Ca (OH) 2 (0. 15G) were added and the suspension warmed to 60C for 3 hours. A further 10ML of warm water was added, then the mixture allowed to cool slowly to room temperature. The precipitate formed was filtered and dried to give atorvastatin calcium salt (0.3g). The material was identical to an authentic sample by mixed melting point, NMR and mass spectrometry., 125995-03-1

The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AVECIA LIMITED; WO2005/12246; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The lactone (V) ( 100.0 g, 0.185 mol) was dissolved in THF (500 ml) and reacted with the suspension of calcium hydroxide ( 18.68 g, 0.185 mol) in water ( 100 ml) and stirred at 45 to 5O0C. After the reaction was over, ( 2 hrs ) the mixture was poured into water(1.0 It) and extracted twice with dichloromethane (3.0 It and 1.0 It each), the combined organic layer was washed with water( 250 ml), dried over sodium sulfate and distilled off completely to obtain a viscous residue. The residue was dissolved in methanol (500 ml), optionally treated with charcoal (5 .0 g), stirred for 30 min at 25 to 3O0C and the solution was successively filtered through hyflow and Whatman filter paper to remove the un-dissolved and suspended particles. The solvent was then distilled under vacuum as described in Example 5 to afford, after sieving through a tea filter funnel, white to off white amorphous Atorvastatin Calcium with a particle size in the range of d5o between 125 to 300 microns and d?io between 300 to 500 microns. Yield: 98.2 g (91.82%); Purity (HPLC): 99.58%; Assay (HPLC): 99.27 %; Calcium content: 3.52 %; Moisture content (by K. F):1.41 %; Residual solvents: Methanol < 0.2%, Dichloromethane <0.01%, THF <0.05%. 125995-03-1, 125995-03-1 Atorvastatin lactone 6483036, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; MOREPEN LABORATORIES LIMITED; WO2006/48893; (2006); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics