With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.
[R-(R*,R*)]-2-(4-fluorophenyl)-beta , delta -dihydroxy-5-(l-methylethyl )-3- phenyl-4-[(phenylamino)carbonyl]-lH-pyrrole-l-heptanoic acid potassium<68> lOOg of atorvastatin lacton was dissolved to 1 L of acetone and 10.38g of potassium hydroxide dissolved in 100 mL of water was added thereto over 1 hour. The reaction solution was stirred for 8 hours at room temperature, the solvent was completely removed by a distillation under reduced pressure, and the residue was distilled under vacuum, suspended to 500 mL of acetone, and filtered. The filtrate was dried for 24 hours at a temperature of 60 C to obtain 95g pf atorvastatin potassium.
125995-03-1, The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTECH CO., LTD.; WO2009/54682; (2009); A2;,
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